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Updated: Jul 20, 2026

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USMLE USMLE Exam Overview:

Certification Vendor:USMLE
Exam Name:United States Medical Licensing Examination
Exam Number:USMLE
Passing Score:Pass/Fail (Step 1)
Exam Duration:480 (Step 1)
Available Languages:English
Related Certifications:USMLE Step 1
USMLE Step 2 Clinical Knowledge (CK)
USMLE Step 3
Exam Format:Computer-based Examination, Multiple Choice Questions (MCQs), Single Best Answer Questions
Real Exam Qty:Up to 280 (Step 1)
Exam Price:USD 680
Certificate Validity Period:No fixed expiration; subject to individual state medical licensure requirements
Sample Questions:USMLE USMLE Sample Questions
Exam Way:Computer-based examination administered at Prometric test centers worldwide.
Pre Condition:Applicants must meet eligibility requirements established by USMLE, including enrollment in or graduation from an accredited medical school recognized by the appropriate authorities.
Official Syllabus URL:https://www.usmle.org/

USMLE Step 1 is a one-day (8 hours) examination. It includes 322 multiple-choice questions divided into 7 blocks of 46 items (60 minutes are given for completion of each block).

USMLE Step 3 is open to candidates who already hold their USMLE Step 1 and Step 2 certificates. Step 3 is a two-day exam that assesses whether candidates are able apply medical knowledge and understanding of biomedical and clinical science essential to unsupervised medical practice. This is the final USMLE exam which leads to the license to practice medicine without supervision - the ultimate goal of medical students and professionals willing to practice medicine in the United States. Step 3 represents the final assessment of physicians assuming independent responsibility for delivering general medical care.

Reference: http://www.usmle.org/step-1/#question-formats

USMLE USMLE Exam Syllabus Topics:

SectionObjectives
Multisystem Processes and Disorders- Systemic Conditions
  • 1. Infectious Diseases
  • 2. Neoplasia
  • 3. Nutrition
Skin and Related Connective Tissue- Dermatologic Conditions
  • 1. Skin Neoplasms
  • 2. Inflammatory Skin Disorders
Human Development- Growth and Development
  • 1. Embryology
  • 2. Developmental Abnormalities
General Principles- Foundational Medical Sciences
  • 1. Genetics
  • 2. Pathology
  • 3. Biochemistry
  • 4. Microbiology
  • 5. Pharmacology
  • 6. Immunology
  • 7. Behavioral Sciences
  • 8. Physiology
Renal and Urinary System- Kidney and Urinary Disorders
  • 1. Renal Pathology
  • 2. Renal Physiology
Cardiovascular System- Cardiac and Vascular Disorders
  • 1. Heart Disease
  • 2. Vascular Pathology
Endocrine System- Hormonal Regulation and Disease
  • 1. Pituitary Disorders
  • 2. Thyroid Disorders
  • 3. Adrenal Disorders
Central and Peripheral Nervous Systems- Neurologic Disorders
  • 1. Neurologic Diseases
  • 2. Neuropathology
  • 3. Neuroanatomy
Reproductive System- Male and Female Reproductive Health
  • 1. Reproductive Disorders
  • 2. Reproductive Physiology
Respiratory System- Pulmonary Medicine
  • 1. Lung Diseases
  • 2. Airway Disorders
Musculoskeletal System- Bones, Joints, and Muscles
  • 1. Rheumatologic Diseases
  • 2. Orthopedic Disorders
Gastrointestinal System- Digestive System Disorders
  • 1. Gastrointestinal Pathology
  • 2. Liver Disease
Hematopoietic and Lymphoreticular Systems- Blood and Immune Disorders
  • 1. Anemias
  • 2. Coagulation Disorders
  • 3. Leukemias and Lymphomas

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